The cardiopulmonary changes among road truck pushers were studied in 200 subjects (100 experimental group and 100 control group). The cardiovascular parameters measured are blood pressure (systolic and diastolic), pulse and mean arterial blood pressure by auscultatory method using stethoscope and sphygmomanometer. The pulmonary parameters measured are peak expiratory flow rate (PEFR), forced expiratory volume in one second (FEV1”) and FEV% by using Wright peak flow meter and vitalograph machine. The cardiopulmonary parameters (systolic and diastolic blood pressure, mean arterial blood pressure, PEFR, FEV1, FEV% and body mass index) of road truck pushers showed an appreciable significant statistical changes (p<.05) when compared to the control group. Keywords: Truck pusher | cardiopulmonary | blood pressure | pulmonary and cardiovascular.