The hypotensive effects of aqueous seed extract of Hibiscus sabdariffa l. were evaluated in normotensive cat. The effects of the aqueous extract were compared with normal basal rhythm and Acetylcholine. The drugs and various doses of the extracts were injected through a cannula inserted in the femoral artery. The extract produced a significant reduction in cat blood pressure. The potency of the extract seems to be high because it has activity at 500:g/ml. The 1mg/ml of the extract exhibited more effective response, however the standard drug Acetylcholine showed a greater potency than the extract. Key words: Acetylcholine, blood pressure, Hibiscus sabdariffa and hypertension